Hand Drawn typography is amazing.
This type art form has its own science. Spacing, Kerning, Leading, and tracking is very important. Each letter has its own anatomy and is very important to how it is used. Some companies pay a lot of money to have letters made for them.
You could go to school specifically for this field. There a a few masters that have done some amazing things with type. On the bottom I have attached some videos that I like and find to be a great inspiration. I am finding typography to be very interesting and something that I wish to learn a lot more on.
-Izzy
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[youtube http://www.youtube.com/watch?v=FOK4sK06YGI] here is some hand drawn typeface in action. [vimeo http://www.vimeo.com/45232468 w=500&h=281]
Inge Druckrey: Teaching to See from Edward Tufte on Vimeo.
this video is very informative and a must watch if you have seen Helvetica.